Modafinil in the Treatment of Excessive Fatigue: What Are the Side Effects?
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Modafinil in the Treatment of Excessive Fatigue: What Are the Side Effects?

There are many side effects associated with using Modafinil in the treatment of excessive fatigue, but few are as serious as the ones caused by caffeine. Here are some of the most common ones. Read on to learn more. Modafinil, Armodafinil, and Caffeine: What Are the Side Effects? as well as How to Avoid Them


The first clinical trial on the drug, entitled Modafinil and Shift Work Sleep Disorder, showed promising results. The medication significantly reduced daytime sleepiness, sleep latency, and clinical impression ratings in healthy volunteers. Furthermore, Modalert significantly improved the patients’ self-reported measures of sleepiness, including the Epworth sleepiness scale. However, the study was short-term and the results cannot be generalize to the entire shift-work population.

Although the American Academy of Sleep Medicine has yet to recognize excessive daytime sleepiness as an illness, the drug has been link to the concept of chronic tiredness. This association is largely due to journal advertising and experts’ opinions about the effects of various products on daytime sleepiness. Despite these conflicting findings, modafinil is currently the only medication approve by the American Academy of Sleep Medicine for this disorder.


Recent studies of armodafinil show that it can effectively reduce excessive daytime sleepiness in patients with narcolepsy, a common disorder. It has also shown promising results in people with shift-work sleep disorder. However, these studies do not show long-term effects. While armodafinil is generally consider safe, health-care providers should monitor patients for cardiovascular complications and other adverse reactions.

While armodafinil is often prescribe for people suffering from OSAHS, it is important to remember that it is not a cure for the disorder itself. It will not cure your sleep disorder and should not be use in place of other sleep disorders, such as obstructive sleep apnea. It is also important to follow your doctor’s instructions and not stop taking armodafinil without first consulting a doctor.


Caffeine is one of the most frequently prescribe medications for chronic sleep problems. It has profound effects on sleep and wake function. It enhances alertness during sleep restriction, sleep deprivation, and circadian sleep cycle reversals. The degraded function can be due to several factors, including basal sleep insufficiency, rebound sleepiness, or circadian rhythm reversals. However, caffeine can lead to dependence in the long term, especially at low doses and after short-term regular use.

One study showed that caffeine had no effect on the REM stage of sleep. People who drink coffee or take nicotine can metabolize caffeine more rapidly. However, women who are pregnant or take oral contraceptives have slower metabolization. Also, the dose of caffeine in food and drinks may have a significant effect on sleep. Whether it is safe to consume caffeine may depend on the strength of the medication and the frequency of use.

Common side effects

Modafinil is a drug that is commonly take orally, usually an hour before the start of a shift. The dosage of modafinil depends on the condition and response to treatment. To reduce the risk of side effects, the medication should be taken regularly and at the same time every day. If taken suddenly, withdrawal symptoms may occur. This is particularly likely to happen if a person has been taking it for a long time and/or take a high dose.

Although the safety of modafinil in pediatric patients has not been establish, there are reports of serious skin rashes, including Stevens-Johnson Syndrome. It is important to keep the patient informed of all medications, particularly alcohol and marijuana, to avoid the risk of a reaction to modafinil. Although a patient with narcolepsy may not be aware of their drowsiness, they should not engage in risky activities or take drugs that make them sleepy.


In this study, researchers evaluated the safety of Modalert 200 in patients with excessive daytime sleepiness. In addition to assessing safety, the researchers also assessed the effects of the drug on clinical symptoms, sleep quality, and nighttime sleep latency. The results show that modafinil was well-tolerate, with no apparent differences among the four dose regimens and no treatment discontinuations related to adverse events.

The safety of Modafinil in the treatment of excess daytime sleepiness was assessed in a randomized controll trial. The treatment groups were compared base on their BMI and their SSMS. Both groups showed a similar level of sleepiness, with the exception of one case in which the modafinil group had a higher baseline BMI than the placebo group. Visit allDayawake for more information.

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